Epidemiology of human papillomavirus infection and. The epidemiology and disease associations of hpv infections will be. The epidemiology of genital human papillomavirus infection. The epidemiology of human papillomavirus infection. Lorraine hickey health protection surveillance centre. They can cause warts on different parts of your body. Genital human papillomavirus infection in female university students as determined by a pcrbased method. Epidemiology, pathogenesis, and therapy jessica severson, tanya y. Epidemiology abstract cervical cancer has been recognized as a rare outcome of a common, sexually transmitted infection whose etiologic association is restricted to a few human papillomavirus hpv types. Epidemiology of genital human papillomavirus infection. Human papillomavirus hpv represents a diverse group of viruses infecting mainly epithelial and mucosal tissues 1. Prevalence and incidence of human papillomavirus hpv infection before and after pregnancy.
However, there are still many unanswered questions concerning the interaction of the virus with its host. The introduction of human papillomavirus hpv vaccination aims to reduce the incidence of cervical cancer. Using data from multiple international studies, the median oncogenic hpv prevalence among all women was 15. Pdf molecular epidemiology of human papillomavirus. Core concepts human papillomavirus infection pathogen. Based on the identity of the l1 major capsid gene sequence, the majority of the over 200 viral types characterized to date cluster within the alpha. Epidemiology of humanpapilloma virus infection among women.
Pdf the epidemiology of human papillomavirus infection and. Pinkbook hpv epidemiology of vaccine preventable diseases. Although there is a higher reported prevalence of all hpvrelated cancer in women, the prevalence of oropharyngeal squamous cell carcinoma opscc is about four times greater in men. Small dna virus more than 150 types first vaccine was licensed in 2006 human papillomavirus hpv disease. We examined psychosocial predictors of hpv vaccine uptake and the association between vaccine intention and uptake 1 year later in adolescent girls aged 1617 years in england. Human papillomavirus hpv is a group of related viruses. It is believed that approximately 20 million americans are currently. More than 170 types of hpv have been classified and more than 40 types of hpv can infect the genital tract of humans. The epidemiology of the human papillomavirus related to. Prevalence of human papillomavirus and subtype distribution in.
Human papillomavirus hpv is one of the most common sexually transmitted infections stis. Human papillomavirus infection and cervical cancer. To summarize the epidemiology of human papillomavirus hpv. Unraveling the epidemiology of oral human papillomavirus. To determine whether there is a difference in the proportion of hpvattributable opc between men and women, we systematically. Human papillomavirus hpv infection is estimated to be the most common sexually transmitted infection.
They can also spread through other intimate, skintoskin contact. The human papillomavirus hpv is a relatively small nonenveloped virus that contains a doublestranded closed circular dna genome, associated with histonelike proteins and protected by a capsid formed by two late protei ns, l1 and l2. Rates of acquisition of hpv are high, particularly among sexually active young adults. Human papillomavirus infection std modules national. Abstract infection with oncogenic human papillomavirus hpv types is a necessary cause of cervical cancer, the second most frequently occurring cancer in women worldwide. Among many types of hpv, around 15 are linked to cancer. The epidemiology of human papillomavirus infections. The human papillomavirus hpv selfstudy std module is intended for the following clinicians who desire a basic introduction to std diagnosis and management.
Who weekly epidemiological record, 12 may 2017, vol. Association of human papillomavirus with vulvar and. The epidemiology of human papillomavirus infection and. Koutsky1 uw hpv research group, lake union place, suite 300, 1914 n.
About 40 of them are spread through direct sexual contact with someone who has the virus. Pdf cervical cancer has been recognized as a rare outcome of a common sexually transmitted infection sti. Predicting human papillomavirus vaccination behaviour. Human papillomavirus infection poland pdf ppt case. Persistent viral infection with highrisk hpv genotypes causes virtually all cancers of the cervix. The highrisk hpv genotypes or types 16 and 18 cause approximately 70 percent of all cervical cancers worldwide, and types 31, 33, 45, 52, and. Pdf epidemiology and prevention of human papillomavirus. Human papillomavirus hpv infection is the main etiological factor for the development of cervical cancer. The burden of oral cancer in the united states has been evolving for at least 2 decades. The threedose vaccine is highly effective, providing protection against hpv types 16 and 18, which are responsible for approximately 70% of cervical cancers. The prevalence and risk of human papillomavirus infection. There are more than 100 varieties of hpv, but most emphasis is given to the 40 varieties that affect the genitals, mouth, or throat, that are passed through sexual contact. Tyring journal of cutaneous medicine and surgery 2001 5.
Review the epidemiology of human papillomavirus infections. The relationship of cervical cancer and sexual behavior was suspected for more than 100 years and was established by epidemiologic studies in the 1960s. Cervical cancer is estimated to affect approximately 500 000 women each year, of whom 80% live in developing countries. Hpv infection have clearly and consistently shown that the key determinants of infection in women are the. Human papillomavirus vaccine characteristics three hpv vaccines are licensed in the united states. Background to maximise the benefits of human papillomavirus hpv vaccination, uptake needs to be high. Human papilloma virus hpv causes cancer at genital, oral, and anal sites. Castle, phd c approximately 15 types of human papillomavirus hpv infection cause virtually all cases of cervical cancer. Summarize the epidemiology of human papillomavirus infections in the united states. Human papillomavirus type and disease association cutaneous other types common warts handsfeet mucosal 40 types highrisk types 16,18, others lowgrade cervical abnormalities high grade abnormalities cancer precursors anogenital cancers lowrisk types 6, 11, others lowgrade cervical abnormalities genital warts. Epidemiology of oral human papillomavirus infection christine h. Viral infections contribute as a cause of 1520% of all human cancers. Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population. Penile human papillomavirus dna pre valence by number of sexual partners of husbands of monogamous and non.
Pdf chapter 2 the epidemiology of human papillomavirus. Method adolescent girls in the catchup cohort were recruited from colleges in the south east of. With optimal testing systems hpv dna can be identified in nearly all specimens of invasive cervical cancer, and it is. Pooled analysis of the control arms of efficacy trials of hpv1618 as04adjuvanted vaccine. Uw hpv research group, lake union place, suite 300, 1914 n. Unger, epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population, the journal of infectious diseases, volume 189, issue 1, 1 january 2004, pages 4650. Evans, patricia lee, tehsheng chan, istvan arany, and stephen k. The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model. Epidemiology and prevention of vaccinepreventable diseases skip directly to site content skip directly to page options skip directly to az link centers for disease control and prevention. Infection by oncogenic viruses can promote different stages of carcinogenesis. Vaccine 24s1 2006 s14s115 the epidemiology of genital human papillomavirus infection helen trottiera, eduardo l. Immunology and vaccinepreventable diseases pink book. The prevalence of hpv infection is highest among young women and appears to drop off with increasing age schiffman, 1992.
Here we assessed the prevalence and distribution of hpv genotypes in fujian population. Prevalence of human papillomavirus in cancer of the. Articles in the english language referenced in medlinepubmed from the year 2000 onward. There are wide differences in cervical cancer incidence and mortality by geographic. Human papillomavirus hpv is a viral infection that is passed between people through skintoskin contact. Gains in head and neck cancer control afforded by a period effect of reduced tobacco exposure have been displaced by competing cohort effects of increasing sexual exposure to human papillomavirus hpv infection and subsequent increases in hpvassociated head and neck cancer, particularly. Ethnic differences in human papillomavirus awareness and.
Infection with oncogenic human papillomavirus hpv types is a necessary cause of cervical cancer, the second most frequently occurring cancer in women. The virus has been identified as a necessary causal agent for cervical squamous neoplasia and has been linked to the development of. Epidemiology and prevention of human papillomavirus article pdf available in annali di igiene. For example, while the prevalence of hpv 1618 was 67. The epidemiology of human papillomavirus infection and its. The antigen for the vaccines is the l1 major capsid protein of hpv, produced by using recombinant dna technology. The epidemiology of human papillomavirus infections janet g. Infection with oncogenic human papillomavirus hpv types is a necessary cause of cervical cancer, the second most frequently occurring cancer in women worldwide. Human papillomavirus 175 11 human papillomavirus hpv is the most common sexually transmitted infection in the united states. Most common sexually transmitted infection in the u.
Over the past several decades, knowledge of the biology and epidemiology of human papillomavirus hpv infection has increased tremendously. Epidemiology and biology of cutaneous human papillomavirus. Pdf the epidemiology of human papillomavirus infection. In spite of effective screening methods, cervical cancer continues to be a major public health problem. Epidemiology of oral human papillomavirus infection. Prevalence and type distribution of human papillomavirus hpv in. Oropharyngeal cancer opc is more frequent in men than women mainly due to the heavier and longer duration of smoking in men. Hpv epidemiology overview reservoir human transmission direct contact, usually sexual temporal none. The epidemiology of human papillomavirus infections the oral. L1 proteins selfassemble into noninfectious, nononcogenic. More than 120 different types of the human papillomavirus hpv have been isolated. A total of 8678 women aging from 17 to 84 years olds were recruited from the fujian medical university union hospital in fujian province. Human papillomavirus and related diseases, summary report 2019. Human papillomavirus hpv has a role in the rising incidence of opc in the united states and other highincome countries.
Epidemiological studies investigating risk factors for. Chapter 2 the epidemiology of human papillomavirus infection and its association with cervical cancer. Epidemiological evaluation of human papillomavirus. Chung, 1, 2 ashley bagheri, 1 and gypsyamber dsouza 3, 1 department of oncology, sidney kimmel comprehensive cancer center, johns hopkins medical institute, baltimore, md. Human papillomavirus hpv infection accounts for approximately 5. Human papillomavirus 16 is the major type, accounting for approximately 50% of cases. Epidemiological evaluation of human papillomavirus genotypes and their associations in multiple infections volume 147 raffaele del prete, luigi ronga, raffaella magrone, grazia addati, angela abbasciano, domenico di carlo, giuseppe miragliotta. Human papillomavirus epidemiology and public health mark schiffman, md. In the majority of individuals, hpv infections are transient and asymptomatic with most new infections resolving within 2 years. Introduction human papillomavirus hpv is a sexually transmitted pathogen that causes anogenital and oropharyngeal disease in males and females. Human papillomavirus hpv has been considered to be an etiologic factor for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. Although it is difficult to estimate the overall prevalence of genital human papillomavirus hpv infection, current figures suggest that visible genital warts are present in approximately 1% of sexually active adults in the united states and that at least 15% have subclinical infection, as detected by hpv dna assays.